Delivery of siHIF?1? to Reconstruct Tumor Normoxic Microenvironment for Effective Chemotherapeutic and Photodynamic Anticancer Treatments

The tumor hypoxic microenvironment not only induces genetic and epigenetic changes in cells, immature vessels formation for oxygen demand, but also compromises the efficiency of therapeutic interventions. On other hand, conventional approaches which kill cells or destroy blood to block nutrition supply usually facilitate even harsher microenvironment. Thus, simultaneously relieving strained response represents a promising strategy reverse adverse In present study, an integrated amphiphilic system (RSCD) is designed based on Angiotensin II receptor blocker candesartan siRNA delivery against hypoxia-inducible factor-1 alpha (HIF-1?), aiming at both vascular cellular “relaxation” reconstruct normoxic Both vitro vivo studies have confirmed that HIF-1? expression down-regulated by 70% growth inhibited 60%. therapy enables neovascularization with more complete organized structures obviously increase level inside tumor, results 50% inhibition. Moreover, reconstruction enhances tumor-targeted drug delivery, significantly improves chemotherapeutic photodynamic anticancer treatments.